A Trial to Prevent Opioid Overdose: E.D. Based Intervention & Take-Home Naloxone

This prospective, randomized controlled study tested an emergency department based intervention with 500 heroin and 500 pharmaceutical opioid users at high risk for overdose. The intervention included a brief behavioral change counseling session, overdose education and take-home naloxone. Outcomes included overdose and HIV risk behaviors, overdose occurrence, and health services utilization and costs.