Research Protocols

The Pacific Northwest Node has participated in numerous CTN treatment research protocols and ancillary studies since joining the CTN in 2001, in collaboration with community treatment programs and primary care providers in our region and the broader CTN. In addition, the Pacific Northwest Node manages the CTN Dissemination Library for the whole NIDA Clinical Trials Network.

Current Protocols

CTN-0148
Cocaine Craving and Use Outcomes Secondary Analysis of a Randomized Study to Test the Safety and Effectiveness of Buprenorphine in the Presence of Naltrexone for the Treatment of Cocaine Dependence

CTN-0139
Collaborative Care for Polysubstance use in Primary Care Settings (Co-Care) (NIH HEAL Initiative)
Site: Sea Mar

CTN-0131
Office-Based Methadone versus Buprenorphine to Address Retention in Medication for Opioid Use Disorder (MOUD)– A Pragmatic Hybrid Effectiveness/Implementation Trial
Site: Alameda Health System

CTN-0122
Comprehensive Meta-Analysis of CTN Treatment Outcomes by Race and Sex

CTN-0116
Pharmacist-Integrated Model of Medication Treatment for Opioid Use Disorder
Site: Community Health Care (Tacoma, WA)

CTN-0106
Derivation and Validation of New Measurement-Based Care Tools Derived from the Brief Addiction Monitor

CTN-0102
Rural Expansion of Medication Treatment for Opioid Use Disorder (NIH HEAL Initiative)
Sites: Ferry County Health, Providence Health Care (Colville, WA), St. Mary’s Hospital, and Syringa Hospital

CTN-0102-XR
Rural Expansion of Medication Treatment for Opioid Use Disorder: Randomized Controlled Pilot Trial of Extended-release Buprenorphine vs. Sublingual Buprenorphine-naloxone in Rural Settings (NIH HEAL Initiative)
Site: Providence Health Care (Colville, WA)

CTN-0099
Emergency Department-INitiated bupreNOrphine and VAlidaTIOn Network Trial (ED-INNOVATION) (NIH HEAL Initiative)
Sites: Univ. of Washington Medical Center and Alameda Health Systems, CA

CTN-0099-A-1
Ancillary to ED-INNOVATION study
Site: Alameda Health Systems, CA

CTN-0096 (S. Radin, Co-Investigator)
Culturally Centered MAT for OUD Implementation Facilitation for Primary Care and Addiction Treatment Programs Serving American Indian/Alaska Natives (NIH HEAL Initiative)

Completed Protocols

CTN-0110
Randomized, Double-Blind, Placebo-Controlled Trial of Monthly Injectable Buprenorphine For Methamphetamine Use Disorder (MURB)

CTN-0107
Peer Recovery Support: A Bridge to Treatment for Overdose Survivors (NIH HEAL Initiative)
Site: Providence Everett

CTN-0091 (L.M. Baldwin, Lead-Investigator)
Preventing and Identifying Opioid Use Disorder Using the Six Building Blocks (6BBs) for Improving Opioid Prescription Management (NIH HEAL Initiative)

CTN-0087 (A. Saxon, Co-Investigator)
A Foundation to Examine Reasons for Discontinuation for Buprenorphine Care in the Veterans Health Administration (NIH HEAL Initiative)

CTN-0085 (D. Donovan, Co-Investigator)
Selection Bias-Free Estimation of the Impact of Drug-Focused 12-step Mutual Help Groups (NIH HEAL Initiative)

CTN-0082 (Co-Lead Node)
Implementation Survey of PrEP and Opioid Use Related Services In STI Clinics and Community Based Organizations (CBOs)

CTN-0080
Medication Treatment for Opioid Use Disorder in Expectant Mothers (MOMs)
Site: Swedish Hospital

CTN-0078-ot
Knowledge of and Attitudes About Medication Assisted Treatment within American Indian Communities
Site: Two Northwest Tribes

CTN-0074
Primary Care Opioid Use Disorders (PROUD) Treatment Trial
Site: Multicare Health System

CTN-0069-A1
Retrospective Evaluation of Rapid Buprenorphine Induction in the Emergency Department for Opioid Use Disorder

CTN-0069
Opioid Use Disorder in the Emergency Department
Site: Harborview Medical Center

CTN-0051-A1
Extended-Release Naltrexone vs. Buprenorphine for Opioid Treatment (X:BOT) Genetics Study
Site: Evergreen Treatment Services

CTN-0051
Extended-Release Naltrexone vs. Buprenorphine for Opioid Treatment (X:BOT)
Site: Evergreen Treatment Services

CTN-0048
Cocaine Use Reduction with Buprenorphine (CURB)
Site: Recovery Centers of King County

CTN-0047 (Co-Lead Node)
Screening, Motivational Assessment, Referral, and Treatment in Emergency Departments (SMART-ED): Evaluation of Screening, Brief Intervention, Referral to Treatment (SBIRT) and Booster Session for Drug Use Patients Presenting for Treatment in the Emergency Department

CTN-0044
Web-Delivery of Evidence-Based, Psychosocial Treatment for Substance Use Disorders
Site: Evergreen Manor

CTN-0040-S (Lead Node)
Pattern of Alcohol Use and Alcohol-Related Diagnoses among Drug-Abusing/Dependent Participants

CTN-0034-Ot (Lead Node)
Developing Research Capacity and Culturally Appropriate Research Methods: Community-Based Participatory Research Manual for Collaborative Research in Drug Abuse for American Indians and Alaska Natives

CTN-0033-Ot-3 (Lead Node)
Methamphetamine: Where Does It Fit in the Bigger Picture of Drug Use of American Indian and Alaska Native Communities and Treatment Seekers?

CTN-0031-A-2 (Co-Lead Node)
The Role of Alcohol Consumption Classifications of Alcohol Use Disorders: A Clinical Study

CTN-0031-A-1
An Evaluation of Neurocognitive Function, Oxidative Damage, and Their Association with Treatment Outcomes in Methamphetamine and Cocaine Abusers Site: Recovery Centers of King County

CTN-0031 (Lead Node)
Stimulant Abuser Groups to Engage in 12-Step (STAGE-12): Evaluation of a Combined Individual-Group Intervention to Reduce Stimulant and Other Drug Use by Increasing 12-Step Involvement
Sites: Evergreen Manor, Recovery Centers of King County

CTN-0030-A-1
Collection of Economic Data for the Prescription Opioid Addiction Treatment Study
Site: Providence Behavioral Health Services

CTN-0030
Prescription Opioid Addiction Treatment Study (POATS)
Site: Providence Behavioral Health Services

CTN-0027-A-2
Retention of Suboxone Patients in START: Perspectives of Providers and Patients
Site: Evergreen Treatment Services

CTN-0027-A-1
START Pharmacogenetics: Exploratory Genetic Studies in Starting Treatment with Agonist Replacement Therapies
Site: Evergreen Treatment Services

CTN-0027
START (Starting Treatment with Agonist Replacement Therapy) Study
Site: Evergreen Treatment Services

CTN-0019
Reducing HIV/STD Risk Behaviors: A Research Study for Women in Drug Abuse Treatment
Site: Evergreen Treatment Services

CTN-0018 (Lead Node)
Reducing HIV/STD Risk Behaviors: A Research Study for Men in Drug Abuse Treatment
Site: Evergreen Treatment Services

CTN-0017
HIV and HCV Intervention in Drug Treatment Settings
Site: Recovery Centers of King County

CTN-0015
Women’s Treatment for Trauma and Substance Use Disorders
Site: Residence XII

CTN-0012
Characteristics of Screening, Evaluation, and Treatment of HIV/AIDS, Hepatitis C Viral Infections, and Sexually Transmitted Infections in Substance Abuse Treatment Programs
Sites: Evergreen Treatment Services, Kitsap Recovery Center, Recovery Centers of King County, Triumph Treatment Services

CTN-0008
Assessment of the National Drug Abuse Clinical Trials Network: A Baseline for Investigating the Diffusion of Innovation
Sites: All

CTN-0003
Suboxone (Buprenorphine/Naloxone) Taper: A Comparison of Taper Schedules
Site: Providence Behavioral Health Services