Marijuana, Reproduction, and Pregnancy

Marijuana is the most commonly used illicit drug among women of reproductive age or by women who are pregnant.

It is difficult to be certain about the specific effects of marijuana on pregnancy and the developing fetus, in part because those who use it often use other drugs as well, including tobacco, alcohol, as well as the influence of social and genetic factors13, and ethical and practical problems in conducting prospective longitudinal studies. We don't know enough yet to be certain about all of the possible risks. We do know that THC, the psychoactive component in marijuana, crosses the placental barrier and is secreted into breastmilk of nursing mothers8.  This raises important concerns about the potential impact of maternal marijuana use on the developing child, so to be safe, it is strongly recommended that pregnant and breastfeeding mothers do not use marijuana.

Can Marijuana Use Affect Fertility?

Heavy use of marijuana has been linked to decreased fertility in both men and women. In women, there is evidence that marijuana use may disrupt the menstrual cycle.  In men, a number of studies have found a connection between marijuana use and reduced fertility in men7. Men who smoke marijuana frequently have significantly less seminal fluid, a lower total sperm count, and their sperm behave abnormally, all of which may affect fertility adversely. Marijuana use can also disrupt in vitro fertilization (IVF) procedures, resulting in fewer eggs retrieved and lower chance of fertilization. In one study, women smoking marijuana 1 year before attempting IVF had 25% fewer eggs retrieved and fewer fertilized16. These factors can make it difficult for a woman to become pregnant.

Can Marijuana Use Affect Pregnancy?

THC is known to pass from the mother to the developing fetus through the placenta24. This means that the fetus is affected by any amount of marijuana taken by the pregnant woman, placing it at a greater risk of complications occurring. Secondhand marijuana smoke may result in illness or altered consciousness in infants and young children25. The effect of the passive inhalation of marijuana as a result of breathing in the smoke of others is not quantified, but has been associated with altered consciousness in the infant25 and should be avoided. Any form of smoking can disrupt the supply of oxygen and nutrients to the fetus, which can result in restrictions in the growth of the fetus including overall length, foot length, head size and body weight13.

Mothers using marijuana to treat medical conditions, like chronic pain, should discontinue use while they are pregnant until more information about the potential harms is available. While the use of marijuana appears to relieve reported symptoms of nausea during pregnancy (though it didn't impact the rate of vomiting)4, women should be aware of the fact it has unproven fetal safety and other treatments for morning sickness may be safer. Although marijuana has not been implicated as an agent that causes birth defects17, there is evidence for adverse neuro-developmental effects after prenatal exposure5,9.

Can Marijuana Use Affect the Baby?

Adverse fetal outcomes related to marijuana use during pregnancy remain unclear. There is some evidence, however, that women who use marijuana during pregnancy are more likely to experience placental complications21 and give birth to babies with lower birth weight14,12; temporary poor autonomic control, particularly in terms of regulating their alertness19; and a "hole in the heart"(ventricular septal defect)23.

Research suggests that, at ages three to four years, children of mothers who used marijuana while pregnant have poorer verbal, memory and reasoning ability; poorer motor skills and shorter length of play; and are more likely to be fearful, impulsive, inattentive, hyperactive and delinquent6. These difficulties appear to persist into adolescence, when they may be accompanied by increased depression and anxiety, along with reading and spelling problems and general underachievement at school6. Such deficits may also continue into early adulthood, along with an increased risk for initiation of tobacco and marijuana use19,20.

In addition, there exists some evidence that mothers' marijuana use during pregnancy increases the risk of their children developing childhood cancers, including non-lymphoblastic leukemia, rhabdomyosarcoma (a rare, highly malignant tumor that can occur anywhere in the body), and astrocytoma (a type of brain tumor)11.

Preliminary research suggests that fathers' marijuana use in the year prior to their children's birth is associated with an increased risk of rhabdomyosarcoma in their children10, and that fathers' marijuana use during conception, pregnancy, or post-natally may be associated with an increased risk of Sudden Infant Death Syndrome (SIDS) in their infants15.

Can Marijuana Use Affect Breast Milk?

When a breastfeeding mother uses marijuana, THC passes into the breast milk and thus into the baby, where it can be stored in the baby's fatty tissue for several weeks. Infants exposed to THC through breast milk experience increased tremors, poor sucking, slow weight gain, and poor feeding in the first month of life18,22.  Studies have also suggested marijuana exposure through breast milk could decrease motor development of the child at one year of age8, but little is known for sure about the adverse effects of postnatal marijuana exposure through breastfeeding because of a lack of studies in lactating women.

More research is needed to be certain of the risks to infants from breast milk containing THC, and the American Academy of Pediatrics has recommended that women avoid breastfeeding it they consistently or heavily use marijuana1,2.

Concerned About Your or Your Partner's Use?

A woman planning to become, or already pregnant, and her partner are both advised to stop using marijuana and to talk to a health care provider openly about past use and the potential risks of continued use. Your health care provider needs a complete history in order to best provide you with the care you, your partner, and your baby need. They will also be able to help, or refer you to someone else who can help, you or your partner cut down or quit marijuana use.

References:

  1. American Academy of Pediatrics (AAP). Policy statement: Breastfeeding and the use of human milk. Pediatrics 2012;129(3):e827-e841. http://dx.doi.org/10.1542/peds.2011-3552
  2. American College of Obstetricians and Gynecologists (ACOG), Committee on Obstetric Practice: Committee Opinion on Marijuana use During Pregnancy and Lactation. Number 637, July 2015. http://www.acog.org/Resources-And-Publications/Committee-Opinions/Committee-on-Obstetric-Practice/Marijuana-Use-During-Pregnancy-and-Lactation
  3. Campolongo P, Trezza V, Ratano P, et al. Developmental consequences of perinatal cannabis exposure: behavioral and neuroendocrine effects in adult rodents.  Psychopharmacology 2010;214(1), 5–15. Free online: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3045519/
  4. Chandra K, Ho E, Sarkar M, et al. Characteristics of women using marijuana in pregnancy and their reported effects on symptoms of nausea and vomiting of pregnancy: A prospective, controlled cohort study. J FAST Int 2003;1:e13. Free online: http://www.motherisk.org/JFAS_documents/Marijuana.pdf.pdf
  5. Dahl RE, Scher MS, et al. A longitudinal study of prenatal marijuana use. Effects on sleep and arousal at age 3 years. Arch Pediatr Adolesc Med 1995;149:145-50. http://dx.doi.org/10.1001/archpedi.1995.02170140027004
  6. Faden VB, Graubard BI. Maternal substance use during pregnancy and developmental outcome at age three. J Subst Abse 2000;12(4):329-40. PubMed abstract: http://www.ncbi.nlm.nih.gov/pubmed/11452837
  7. Fronczak CM, Kim ED, Barqawi AB.  The insults of illicit drug use on male fertility [Review].  Journal of Andrology 2012;33(4):515-528.  Free online: http://onlinelibrary.wiley.com/doi/10.2164/jandrol.110.011874/pdf
  8. Garry A, et al. Cannabis and breastfeeding. J Toxicol 2009;2009:596149. http://dx.doi.org/10.1155/2009/596149
  9. Goldschmidt L, Day NL, et al. Effects of prenatal marijuana exposure on child behavior problems at age 10. Neurotox Teratol 2000;22:325036. http://dx.doi.org/10.1016/S0892-0362(00)00066-0
  10. Grufferman S, et al Parents’ use of cocaine and marijuana and increased risk of rhabdomyosarcoma in their children. Cancer Causes Control 1993;4(3):217-24. Pubmed abstract: http://www.ncbi.nlm.nih.gov/pubmed/?term=8318638
  11. Huang YH, et al. An epidemiologic review of marijuana and cancer: an update. Cancer Epidemiol Biomarkers Prev.2015;24(1):15-31. http://dx.doi.org/10.1158/1055-9965.EPI-14-1026
  12. Huizink AC. Prenatal cannabis exposure and infant outcomes: overview of studies. Prog Neuropsychopharmacol Biol Psychiatry 2014;52:45-52. http://dx.doi.org/10.1016/j.pnpbp.2013.09.014
  13. Jaques SC, et al. Cannabis, the pregnant woman and her child: Weeding out the myths. Journal of Perinatology 2014;34:417-424. http://dx.doi.org/10.1038/jp.2013.180
  14. Janisse JJ, Bailey BA, Ager J, Sokol RJ. Alcohol, tobacco, cocaine, and marijuana use: relative contributions to preterm delivery and fetal growth restriction. Subst Abuse 2014;35(1):60-7. http://dx.doi.org/10.1080/08897077.2013.804483
  15. Klonoff-Cohen H, Lam-Kruglick P. Maternal and paternal recreational drug use and sudden infant death syndrome. Arch Pediatr Adolesc Med 2001;155(7):765-770. http://dx.doi.org/10.1001/archpedi.155.7.765
  16. Klonoff-Cohen HS, Natarajan L, Chen RV.  A prospective study of the effects of female and male marijuana use on in vitro fertilization (IVF) and gamete intrafallopian transfer (GIFT) outcomes. Am J Obst Gynecol 2006;194(2):369-76.  http://dx.doi.org/10.1016/j.ajog.2005.08.020
  17. Lee MJ.  Marihuana & tobacco use in pregnancy. Obst Gyn Clin N Amer 1998;25(1):65-81
  18. Miller CW. Marijuana use and breastfeeding. Clinical Lactation 2012;3-3:102-107. Free online: http://dhss.alaska.gov/dpa/Documents/dpa/programs/nutri/wic/newsletters/2012-12-07/MarijuanaBreastfeeding.pdf
  19. Minnes S, Lang A, Singer L. Prenatal tobacco, marijuana, stimulant, and opiate exposure: outcomes and practice implications. Addict Sci Clin Pract. 2011;6(1):57–70. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3188826/
  20. Sonon KE, Richardson GA, Cornelius JR, Kim KH, Day NL. Prenatal marijuana exposure predicts marijuana use in young adulthood. Neurotoxicol Teratol 2015;47:10-5. http://dx.doi.org/10.1016/j.ntt.2014.11.003
  21. Warner TD, Roussos-Ross D, Behnke M. It’s not your mother’s marijuana: effects on maternal-fetal health and the developing child. Clin Perinatol 2014;41(4):877-94. http://dx.doi.org/10.1016/j.clp.2014.08.009
  22. Washington State Dept. of Health. Substance Abuse During Pregnancy: Guidelines for Screening and Management, rev. 2015.
  23. Williams LJ, Correa A, Rasmussen S. Maternal lifestyle factors and risk for ventricular septal defects. Birth Defects Res A Clin Mol Teratol 2004;70(2):59-64. http://dx.doi.org/10.1002/bdra.10145
  24. Wu CS, Jew CP,Lu, HC. Lasting impacts of prenatal cannabis exposure and the role of endogenous cannabinoids in the developing brain. Future Neurology 2011;6(4): 459–480. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3252200/
  25. Zarfin Y, Yefet E, Abozaid S et al. Infant with altered consciousness after cannabis passive inhalation. Child Abuse Negl 2012; 36(2), 81–83.  http://dx.doi.org/10.1016/j.chiabu.2001.09.011


This information adapted with permission from the National Cannabis Prevention and Information Centre in Australia.

    

 

This information made available by the UW Alcohol & Drug Abuse Institute · Updated 9/2015
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